Fig. 2: Immune cell infiltration landscape from mIHC. | npj Precision Oncology

Fig. 2: Immune cell infiltration landscape from mIHC.

From: Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer

Fig. 2: Immune cell infiltration landscape from mIHC.The alternative text for this image may have been generated using AI.

A Immune cell infiltration in tumor and stromal regions among ROIs (log2(number/mm2)), annotated with ILC cluster, PAM50 subtypes, and demographic or clinical information. B Histogram of immune cell type abundance (number/mm2) in stromal and tumor region ROIs. C Spearman correlation (FDR < 0.05) of immune cell infiltration (number/mm2) between cell types. D NMF consensus matrix from immune cell infiltration in both stromal and tumor regions among ROIs, showing 5 immune infiltration patterns. E Stromal region immune cell infiltration (number/mm2) among immune infiltration patterns, showing each pattern per panel. F Stromal region immune cell infiltration (number/mm2) among immune infiltration patterns, showing each immune cell type per panel. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, comparison (horizontal brackets) with no label, p ≥ 0.05. G, H Immune cell infiltration (number/mm2) in proliferative and non-proliferative ILC tumors in stromal (G) and tumor regions (H). I Number of ROIs in each immune infiltration pattern, stratified by ILC subtypes.

Back to article page