Fig. 6: Timing of mutations in MLCs evolution based on the WES cohort.
From: Optimizing the NGS-based discrimination of multiple lung cancers from the perspective of evolution
A Tumor evolution of MLCs, merging MPLC and IPM. B Tumor evolution of IPM. This Figure shows the approximate timing of driver mutations with respect to the cancer life history. Driver genes were screened against the COSMIC database. The timing of mutations is shown as bars indicating whether the events are clonal or subclonal. Clonal mutations are further timed as early, late, or untimed with respect to whole-genome doubling. The frequency of mutations (subclonal and total) is indicated on the right side of the bars. Only genes containing ≥2 driver alterations across the cohort are included. MLCs multiple lung cancers, MPLC multiple primary lung cancers, IPM intrapulmonary metastasis, WES whole-exome sequencing, Pre-GD occurrence before whole-genome doubling, Post-GD occurrence after whole-genome doubling.
