Fig. 7: OSGIN1 decreased the resistance of ovarian cancer to sorafenib in vivo.
From: A targetable OSGIN1 − AMPK − SLC2A3 axis controls the vulnerability of ovarian cancer to ferroptosis
a Relative protein levels of OSGIN1, GLUT3, COX-2 and 4-HNE in mouse tumor tissues. b Representative images of tumors from each group. n = 6 in each group. c Tumor weight in each experimental group. d MDA content in tumor tissues from each group. Cellular GSH/GSSG ratio in tumors from the indicated groups. Cellular iron levels in tumor tissues from the indicated groups. Each experiment was repeated three times. The p values in b were determined by two-way ANOVA with multiple comparisons. Statistical significance in c, d was determined by a two-tailed unpaired t-test. Error bars are s.e.m. *p < 0.05; **p < 0.01 and ***p < 0.001.
