Fig. 5: Gene expression analysis of pancreatic cancer cell lines irradiated with γ-rays or carbon particles. | npj Precision Oncology

Fig. 5: Gene expression analysis of pancreatic cancer cell lines irradiated with γ-rays or carbon particles.

From: Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer

Fig. 5

A Venn-diagram showing numbers of differentially expressed genes after γ-ray or carbon ion irradiations in comparison to sham-irradiated cell lines (FDR < 0.1). B Plot of cell line samples with the top 3 principal components after supervised PCA analysis using 745 differentially expressed genes. C Pathway analysis of differentially expressed genes in response to radiations showed significantly changed signaling pathways (FDR < 0.1 in at least one condition) with activation z-scores. A positive z-score indicated up-regulation and a negative z-score indicated down-regulation of the pathway.

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