Fig. 3: Multiple immunohistochemical and cellular characterization images of negative tumor-draining lymph nodes (TDLN−) and positive TDLN (TDLN+).

Multiple immunohistochemical images of TDLN− and TDLN+ (a). Differences in infiltration of each CD8 subpopulation in lymph node specimens of TDLN− and TDLN+ (b). Scale bar, 100 μm. CD8⁺T_RM CD8⁺ tissue-resident memory T cells, CD8⁺T_RM1 PD-1⁻TIM-3⁻CD8⁺T_RM, CD8⁺T_RM2 PD-1⁺TIM-3⁻CD8⁺T_RM, CD8⁺T_RM3 PD-1⁻TIM-3⁺CD8⁺T_RM, CD8⁺T_RM4 PD-1⁺TIM-3⁺CD8⁺T_RM.