Fig. 4: Cell-Cell interactions in the tumor microenvironment.
From: The single-cell spatial landscape of stage III colorectal cancers
a An overview of Histocat’s random permutation approach for assessing significant interactions or avoidance between cell type pairs at the tissue region level, b quantitative interaction scores for identifying significant pairwise cell interactions between two conditions, c homotypic interactions shown as the logarithmic fold-change (LogFC) of interacting versus avoiding tissue regions, d heterotypic interactions highlighting the top 10 most engaged and avoided pairs, e boxplots comparing interaction scores between MSI-H and MSS samples, displaying the 5 lowest adjusted p-values, f boxplot of interaction scores between two cell types in MSS samples, comparing cases with and without recurrence.
