Fig. 5: Cell neighborhoods (CN) in Stage III colorectal cancer.
From: The single-cell spatial landscape of stage III colorectal cancers
a definition of cell neighborhoods with three examples, b K-means clustering identifies 8 distinct CNs, with a heatmap showing the cell type composition for each cluster (x-axis: cell types; y-axis: CNs), c Stacked bar plot of CN composition in each patient’s tumor, categorized by MSI status and ordered by CD8 + T cell-enriched CN proportion, d Example tissue region from a patient with the most abundant CD8 + T cell-enriched CNs, e from a patient with the least abundant CD8 + T cell-enriched CNs, f Overall abundance of each CN across all samples, g and h correlation correlograms between different CN proportions among MSS patients with and without recurrence, only showing significant relationships (adjusted p ≤ 0.05). The scale bar indicates correlation strength across tissue regions.
