Fig. 2: Comparison of primary and metastatic lesions in Patient 2.
From: Revealing neuroendocrine transformation in gynecological cancers through genomic analysis
A Histologic examination of the primary uterine neoplasm (top panel) shows complex branching glands composed of pseudostratified back-to-back columnar epithelium (shown at 10X and 40X magnification) consistent with low-grade endometrioid carcinoma. Histologic examination of the lung neoplasm (middle panel) demonstrates sheets of cells with a high nuclear-to-cytoplasmic ratio and nuclear molding (shown at 10X and 40X magnification). Lung tumor cells are negative for PAX8, but positive for chromogranin (lower panel), indicating neuroendocrine differentiation (shown at 20X). B Comparison of the single nucleotide variants and indels (and their variant allele fractions, VAFs) between the uterine neoplasm and neuroendocrine metastasis revealed multiple shared somatic findings, confirming their clonal relationship (shared variants are highlighted in yellow).
