Table 1 Evolution in time of chromosomal aberrations in cell-free and genomic DNA from WBC, as measured by GIPSeq and FISH, respectively
From: Copy-number alterations in cell-free DNA can be transient or harbingers of clonal hematopoiesis
Case | Age at follow-up (years) | Sex | GIPseq profile at initial study a | GIPseq profile at follow-upa | GIPseq Evolution | ∆T (years)b | FISH results at follow-up |
|---|---|---|---|---|---|---|---|
20042017-10 | 84 | F | del(9q) | del(9q) | Status quo | 3.4 | nuc ish(CEP9×2,RP11-23B15×1,RP11-176L21×1)[21/100] |
21042016-06 | 81 | M | dup(14q) | dup(14q) | Status quo | 4.4 | NA |
18022016-01 | 75 | M | +15 | +15 | Status quo | 4.7 | nuc ish(PML×3,RARAx2)[8/200] |
30032017-02 | 71 | M | +15 | +15 | Status quo | 3.4 | nuc ish(PML×3,RARAx2)[2/100] |
16022017-08 | 75 | F | +15 | +15 | Status quo | 3.6 | nuc ish(PML×3,RARAx2)[4/100] |
29042016-27 | 81 | F | del(5q) | Multiple chromosomes; del(5q) | Progression | 4.5 | nuc ish(D5S23×2,EGR1×1)[35/100] |
02022017-08 | 69 | M | Multiple chromosomes | Multiple chromosomes; +15 | Progression | 3.8 | nuc ish(PML×3,RARA×2)[3/100] |
17112016-02 | 72 | M | dup(9p)/dup(9q) | normal | Normalization | 3.9 | Not performed* |
06022017-06 | 84 | M | Multiple chromosomes; −17 | normal | Normalization | 3.6 | Not performed* |
