Fig. 1: Bioinformatics analysis reveals NSUN2 as an oncogene in prostate cancer. | npj Precision Oncology

Fig. 1: Bioinformatics analysis reveals NSUN2 as an oncogene in prostate cancer.

From: FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner

Fig. 1

A, B Relative expression of m5C “Writers” in prostate cancer (PRAD) tissues, as analyzed from the TCGA (A) and GSE46602 (B) databases. C, D Forest plots displaying univariate Cox regression analyses for Disease-Free Survival(DFS) (C) and Progression-Free Survival(PFS) (D), adjusted for m5C regulators in PRAD. The plots show hazard ratios along with their 95% confidence intervals. E Changes in the expression of m5C methyltransferases following castration. The relative expression levels of gene mRNA are derived from GSE8702. F Temporal changes in the NSUN2 expression levels in prostate cancer post-castration. The relative expression levels of gene mRNA are derived from GSE8702. G Variability in the mutation status of hotspot genes across different stages. The gene mutation data is sourced from the TCGA, MSKCC, and SU2C projects.

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