Fig. 8: Schematic illustration of CEACAM6-mediated EGFR signaling in lung adenocarcinoma. | npj Precision Oncology

Fig. 8: Schematic illustration of CEACAM6-mediated EGFR signaling in lung adenocarcinoma.

From: Cytokine and epigenetic regulation of CEACAM6 mediates EGFR-driven signaling and drug response in lung adenocarcinoma

Fig. 8

CEACAM6 interacts with EGFR, enhancing EGFR stability and maintaining epithelial morphology, thereby promoting lung cancer cell growth. TGF-β stimulation and epigenetic regulation downregulate CEACAM6, shifting toward EGFR-independent signaling and consequent EGFR-TKI resistance characterized by elevated EMT features.

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