Table 1 Patient demographics and clinical characteristics across four molecular clusters of Ipi/Nivo arm of BIONIKK trial
Cluster1 | Cluster2 | Cluster4 | Cluster5 | Pcluster1/2 vs. 4/5 | |
|---|---|---|---|---|---|
No. of sample | 12 (24%) | 15 (31%) | 16 (33%) | 6 (12%) | |
Age | 0.047 | ||||
≤60 | 2 (17%) | 7 (47%) | 9 (56%) | 5 (83%) | |
>60 | 10 (83%) | 8 (53%) | 7 (44%) | 1 (17%) | |
Sex | 1 | ||||
Female | 2 (17%) | 0 | 1 (6%) | 1 (17%) | |
Male | 10 (83%) | 15 (100%) | 15 (94%) | 5 (83%) | |
Sarcomatoid | 0.117 | ||||
Absence | 11 (92%) | 14 (93%) | 13 (81%) | 3 (50%) | |
Presence | 1 (8%) | 1 (7%) | 3 (19%) | 3 (50%) | |
IMDC | 0.040 | ||||
Favorable | 6 (50%) | 9 (60%) | 4 (25%) | 1 (17%) | |
Intermediate/Poor | 6 (50%) | 6 (40%) | 12 (75%) | 5 (83%) | |
ORR | 0.029 | ||||
CR | 2 (17%) | 5 (34%) | 0 | 0 | |
PR | 6 (50%) | 6 (40%) | 7 (44%) | 2 (33%) | |
SD | 2 (17%) | 2 (13%) | 5 (31%) | 0 | |
PD | 2 (17%) | 2 (13%) | 4 (25%) | 4 (66%) | |
Descartes | 0.007 | ||||
ccrcc1 | 10 (83%) | 2 (13%) | 4 (25%) | 4 (66%) | |
ccrcc2 | 2 (17%) | 12 (80%) | 4 (25%) | 1 (17%) | |
ccrcc3 | 0 | 0 | 0 | 1 (17%) | |
ccrcc4 | 0 | 1 (7%) | 8 (50%) | 0 |
