Fig. 5: Cell-to-cell communications among thyrocyte and immune cells predicted by the CellChat software in PTC and ATC. | npj Precision Oncology

Fig. 5: Cell-to-cell communications among thyrocyte and immune cells predicted by the CellChat software in PTC and ATC.

From: Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer

Fig. 5

A Circle plot summarizing the maximum number of interactions among individual cell types in PTC. The thickness of the lines connecting cells indicates the interaction strength. B The same plot as in (A) but applied to ATC. C Differences of number and strength overall information flow within the inferred networks between PTC and ATC. D The potential outgoing and incoming interaction strength of each cellular cluster in PTC and ATC. Heatmap showing the relative signaling contribution of each cell group based on the number and strength compared PTC with ATC. E Heatmap showing the relative signaling contribution of each cell group based on the number and strength compared PTC with ATC. F Differential strength of network centrality based on APOE+ macrophages (PTC vs. ATC). G Bubble heatmap showing the cell–cell communication of selected ligand–receptor pairs between APOE+ macrophage and CD8+ PDCD1+ T cells. Dot size indicates P value, colored by communication probability. H Multiplex IHC shows the cross-talk between APOE+ macrophages and T cells via the ligand–receptor of THBS1-CD47.

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