Fig. 8: Predicted cell–cell interactions of onco-fetal reshaping in Normal, PTC and Metastase. | npj Precision Oncology

Fig. 8: Predicted cell–cell interactions of onco-fetal reshaping in Normal, PTC and Metastase.

From: Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer

Fig. 8

A Expression of top 20 predicted ligands identified by NicheNet analysis based on the differentially expressed signature genes of RBP7+ endothelial cells in Normal, PTC and Metastase. B Expression of top 20 predicted ligands identified by NicheNet analysis based on the differentially expressed signature genes of EMT-like CAFs in Normal, PTC and Metastase. C Expression of top 20 predicted ligands identified by NicheNet analysis based on the differentially expressed signature genes of APOE+ macrophages in Normal, PTC and Metastase. D Heatmap depicting the expression of shared potential ligands driving hub niche reprogramming in Normal, PTC and Metastase.

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