Fig. 3: MCC regression is associated with increased TCR clonality, heightened representation of dominant clones, and the emergence of new high-frequency clones. | npj Precision Oncology

Fig. 3: MCC regression is associated with increased TCR clonality, heightened representation of dominant clones, and the emergence of new high-frequency clones.

From: Spontaneous tumor regression and immunotherapy response demonstrate clonal T-cell expansion in Merkel cell carcinoma

Fig. 3

A Map of the 100 most dominant individual T-cell clones, averaged across paired baseline and regressing tumor samples, organized from most to least frequently represented in tumors with spontaneous tumor regression (“STR Patient”) and regression after avelumab treatment (“ICI Patient”). B Both tumors displayed an increase in T-cell receptor clonality during regression when compared to their baseline.

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