Table 2 Multivariable COX proportional hazard model for overall survival in two cohorts

Clinic-pathological variables

Hazard ratio (95% CI)

p

Hazard ratio (95% CI)

p

 Age (per unit)

0.61 (0.49–1.32)

<0.001

1.03 (1.03–1.04)

<0.001

 Stage (Late vs. Early)

4.29 (2.73–6.74)

<0.001

1.96 (1.70–2.26)

<0.001

 Her2 status

 Her2 zero

Reference

Reference

 Her2 low

0.62 (0.39–0.97)

0.037

0.63 (0.55–0.73)

<0.001

 Her2 positive

0.73 (0.40–1.32)

0.297

0.51 (0.42–0.61)

<0.001

Ki67 status

 <15%

Reference

Reference

 15–35%

2.23 (1.30–3.81)

0.004

1.88 (1.57–2.26)

<0.001

 >35%

2.07 (1.13–3.79)

0.018

2.57 (2.09–3.15)

<0.001

Histologic type

 Invasive ductal carcinoma

Reference

Reference

 Invasive lobular carcinoma

1.94 (0.70–5.40)

0.206

0.90 (0.74–1.09)

0.293

 Others

1.29 (0.61–2.70)

0.504

0.90 (0.70–1.14)

0.377

Intravascular cancer thrombus (Yes vs. No)

2.41 (1.44–4.01)

<0.001

1.32 (1.14–1.53)

<0.001

Endocrine therapy (Yes vs. No)

0.59 (0.35–0.98)

0.042

0.58 (0.51–0.66)

<0.001

Her2 target therapy (Yes vs. No)

0.42 (0.15–1.18)

0.099

0.69 (0.52–0.92)

0.012

Radiation therapy (Yes vs. No)

0.56 (0.36–0.89)

0.013

0.69 (0.52–0.92)

<0.001