Fig. 3: HRD+ rate associated with individual non-BRCA1/2 HRR gene by variant origin and hit type. | npj Precision Oncology

Fig. 3: HRD+ rate associated with individual non-BRCA1/2 HRR gene by variant origin and hit type.

From: Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations

Fig. 3: HRD+ rate associated with individual non-BRCA1/2 HRR gene by variant origin and hit type.

a HRD+ rate associated with germline P/LP variations and VUS of individual non-BRCA1/2 HRR gene. b HRD+ rate associated with somatic II and III variations of individual non-BRCA1/2 HRR gene. c HRD+ rate related with germline P/LP BA and MA variations of individual non-BRCA1/2 HRR gene. d HRD+ rate related with somatic II BA and MA variations of individual non-BRCA1/2 HRR gene. BAs biallelic alterations, HRD homologous recombination deficiency, LP likely pathogenic, MAs monoallelic alterations, P pathogenic, VUS variants of uncertain significance.

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