Fig. 1: Cell populations of 93 samples across the progression of lung disease.

a Schematic of the data generation, study design and the statistics of single-cell data from different datasets. b Uniform manifold approximation and projection (UMAP) analysis of all cells, colored by cell types. c UMAP plots showing expression of canonical marker genes of major cell populations. d The expression levels of representative signature genes. e Stacked barplot showing proportions of major cell populations across groups. Colors represent major cell populations. f Heatmap showing tissue preferences of major cell population in each groups revealed by Ro/e.