Fig. 3: Histological characteristics varied between patches of high and low TR-scores. | npj Precision Oncology

Fig. 3: Histological characteristics varied between patches of high and low TR-scores.

From: AI-powered prediction model for neoadjuvant chemotherapy efficacy: comprehensive analysis of breast cancer histological images

Fig. 3: Histological characteristics varied between patches of high and low TR-scores.

Low TR-score patches (upper) showed more uniform nuclei, less nuclear atypia, and tumor epithelial cells arranged in nests or cord-like structures, accompanied by abundant fibroblasts and collagen fibers in the stroma. High TR-score patches (bottom) exhibited darker tumor nuclei staining, greater nuclear atypia, frequent mitotic figures, and prominent perinuclear halos. The tumor epithelium grew in solid sheets with abundant lymphocytic infiltration in both epithelial and stromal regions.

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