Fig. 5: Impact of loss function weighting on ALK trade-off plots.
From: Predicting ROS1 and ALK fusions in NSCLC from H&E slides with a two-step vision transformer approach
Trade-off plots for the ALK test sets with varying positive weights in the loss function: 5 (A), 10 (B), 20 (C), and 30 (D). The x-axis shows the false negative rate (false negatives as a proportion of total cases), while the y-axis shows the true negative rate (true negatives as a proportion of total cases) for the red curve and PPA for the blue curve. As the positive weight increases, the blue curve shifts toward the top-left, reflecting enhanced PPA and fewer false negatives, while the red curve moves toward the bottom-left, reflecting a reduction in true negatives.
