Fig. 5: Identification of selective genetic dependencies in p53abn and MMRd ECs. | npj Precision Oncology

Fig. 5: Identification of selective genetic dependencies in p53abn and MMRd ECs.

From: Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities

Fig. 5

a Comparison of genetic dependency in 16 MMRd EC cell lines vs 9 p53abn EC cell lines. Genome-wide CRISPR screen data was downloaded from the DepMap database (23Q2). MMRd EC cell lines: COLO684, MFE296, JHUEM1, HEC1B, HEC265, ISHIKAWAHERAKLIO02ER, RL952, SNGM, EN, HEC6, MFE319, HEC59, HEC1, HEC116, HHUA and HOUAI; p53abn EC cell lines: MFE280, KLE, SNU1077, TEN, SNU685, EFE184, HEC50B, EMTOKA and HTMMT. b Western blotting showing PELO knockout by CRISPR/Cas9 in MMRd and p53abn EC cells. Representative images (c) and quantitation (d) of the effect of PELO deletion on the growth of MMRd EC cell lines. Error bars represent SEM and p-values were determined using Tukey multiple comparison test.

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