Table 2 Clinicopathological features and performance of Deepath-MSI model in the real-world validation set
| Â | Number | dMMR | pMMR | dMMR ratio | p | Accuracy | p | Sensitivity | p | Specificity | p | PPV | p | NPV | p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Overall | 2236 | 111 | 2125 | 5.00% | Â | 90.90% | Â | 94.60% | Â | 90.70% | Â | 34.70% | Â | 99.70% | Â |
Gender | |||||||||||||||
 Male | 1376 | 59 | 1317 | 4.30% | 0.071 | 90.80% | 1.000 | 91.50% | 0.212 | 90.80% | 0.818 | 30.90% | 0.113 | 99.60% | 0.418 |
 Female | 860 | 52 | 808 | 6.00% | 90.90% | 98.10% | 90.50% | 39.80% | 99.90% | ||||||
Age | |||||||||||||||
 Median (IQR) | 62 (54, 69) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
 <50 | 298 | 27 | 271 | 9.10% | 0.001 | 89.30% | 0.330 | 96.30% | 1.000 | 88.60% | 0.218 | 45.60% | 0.064 | 99.60% | 0.551 |
 ≥50 | 1938 | 84 | 1854 | 4.30% | 91.10% | 94.00% | 91.00% | 32.10% | 99.70% | ||||||
Primary tumor site | |||||||||||||||
 Rectum | 969 | 13 | 956 | 1.30% | <0.001 | 94.00% | <0.001 | 76.90% | 0.033 | 94.20% | <0.001 | 15.40% | 0.002 | 99.70% | 0.945 |
 Sigmoid colon | 350 | 9 | 341 | 2.60% | 92.90% | 88.90% | 93.00% | 25.00% | 99.70% | ||||||
 Ascending colon | 321 | 43 | 278 | 13.40% | 82.60% | 97.70% | 80.20% | 43.30% | 99.60% | ||||||
 Rectosignmoid colon | 202 | 5 | 197 | 2.50% | 93.10% | 80.00% | 93.40% | 23.50% | 99.50% | ||||||
 Descending colon | 106 | 8 | 98 | 7.50% | 91.50% | 100.00% | 90.80% | 47.10% | 100.00% | ||||||
 Transverse colon | 103 | 15 | 88 | 14.60% | 83.50% | 100.00% | 80.70% | 46.90% | 100.00% | ||||||
 Others | 185 | 18 | 167 | 9.70% | 86.50% | 100.00% | 85.00% | 41.90% | 100.00% | ||||||
Primary tumor site (Left/Right)a | |||||||||||||||
 Left hemicolon | 730 | 28 | 702 | 3.80% | <0.001 | 92.70% | <0.001 | 92.90% | 0.196 | 92.70% | <0.001 | 33.80% | 0.159 | 99.70% | 1.000 |
 Right hemicolon | 518 | 70 | 448 | 13.50% | 82.60% | 98.60% | 80.10% | 43.70% | 99.70% | ||||||
Tumor size (cm)b | |||||||||||||||
 <3 | 463 | 15 | 448 | 3.20% | <0.001 | 92.90% | <0.001 | 100.00% | 0.238 | 92.60% | <0.001 | 31.30% | 0.105 | 100.00% | 0.339 |
 3 ~ 6 | 1450 | 51 | 1399 | 3.50% | 92.30% | 90.20% | 92.40% | 30.30% | 99.60% | ||||||
 >6 | 311 | 45 | 266 | 14.50% | 81.00% | 97.80% | 78.20% | 43.10% | 99.50% | ||||||
Histological type | |||||||||||||||
 Adenocarcinoma | 2021 | 86 | 1935 | 4.30% | <0.001 | 92.20% | <0.001 | 94.20% | 0.573 | 92.10% | <0.001 | 34.60% | 0.205 | 99.70% | 0.239 |
 Adenocarcinoma with mucus | 94 | 14 | 80 | 14.90% | 85.10% | 100.00% | 82.50% | 50.00% | 100.00% | ||||||
 Mucinous adenocarcinoma | 72 | 9 | 63 | 12.50% | 65.30% | 88.90% | 61.90% | 25.00% | 97.50% | ||||||
 Others | 49 | 2 | 47 | 4.10% | 85.70% | 100.00% | 85.10% | 22.20% | 100.00% | ||||||
Tumor differentiationc | |||||||||||||||
 Well | 33 | 2 | 31 | 6.10% | <0.001 | 84.80% | <0.001 | 100.00% | 0.065 | 83.90% | <0.001 | 28.60% | 0.201 | 100.00% | 0.155 |
 Well-moderate | 104 | 3 | 101 | 2.90% | 91.30% | 66.70% | 92.10% | 20.00% | 98.90% | ||||||
 Moderate | 1273 | 45 | 1228 | 3.50% | 92.50% | 91.10% | 92.50% | 30.80% | 99.60% | ||||||
 Moderate-poorly | 622 | 43 | 579 | 6.90% | 91.30% | 100.00% | 90.70% | 44.30% | 100.00% | ||||||
 Poorly | 177 | 17 | 160 | 9.60% | 79.70% | 94.10% | 78.10% | 31.40% | 99.20% | ||||||
Number of tiles | |||||||||||||||
 100 ~ 200 | 80 | 4 | 76 | 5.00% | 0.027 | 92.50% | 0.316 | 50.00% | 0.011 | 94.70% | 0.107 | 33.30% | 0.551 | 97.30% | 0.033 |
 200 ~ 500 | 544 | 17 | 527 | 3.10% | 92.30% | 94.10% | 92.20% | 28.10% | 99.80% | ||||||
 500 ~ 1000 | 1163 | 57 | 1106 | 4.90% | 90.90% | 94.70% | 90.70% | 34.40% | 99.70% | ||||||
 >1000 | 449 | 33 | 416 | 7.30% | 88.90% | 100.00% | 88.00% | 39.80% | 100.00% | ||||||
