Fig. 2: Differentially expressed miRNAs were identified between responders and non-responders (fold change > ± 1.5 and p value < 0.05). | npj Precision Oncology

Fig. 2: Differentially expressed miRNAs were identified between responders and non-responders (fold change > ± 1.5 and p value < 0.05).

From: Circulating miRNAs as potentially predictive biomarkers for chemoimmunotherapy in advanced biliary tract cancer: a post-hoc analysis of the phase II T1219 study

Fig. 2

a Three miRNAs were differentially expressed in advanced BTC. hsa-miR-16-5p, hsa-miR-93-5p, and hsa-miR-126-3p were up-regulated significantly in responders. The predictive value of the miRNA-based therapeutic response classifier was analyzed using the ROC curve. b Prediction model combining all three miRNAs using logistic Lasso regression showed the best AUC value at 0.81 compared to the models built on each individual miRNA. 95% confidence intervals are shown in parentheses.

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