Fig. 7: Stability analysis varying thresholds and cut-points of the PD-L1 QCS-defined percentage of positive tumor cells. | npj Precision Oncology

Fig. 7: Stability analysis varying thresholds and cut-points of the PD-L1 QCS-defined percentage of positive tumor cells.

From: Enhanced patient selection with quantitative continuous scoring of PD-L1 expression for IO treatment in metastatic NSCLC

Fig. 7

The yellow rhombus indicates the discovered parameterization of QCS-PMSTC with SI = 40 as cell positivity threshold together with a cut-point of 0.575% for patient categorization. Subfigure a shows the p-values obtained for cox interaction terms for Durvalumab vs. SoC arm upon variation of both parameters and b the p-value of log-rank testing respectively the hazard ratio for stratification in the Durvalumab arm.

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