Fig. 8: Overview of the PD-L1 QCS analysis pipeline. | npj Precision Oncology

Fig. 8: Overview of the PD-L1 QCS analysis pipeline.

From: Enhanced patient selection with quantitative continuous scoring of PD-L1 expression for IO treatment in metastatic NSCLC

Fig. 8

In the first step (left), WSI are inspected and pathologists’ annotation of the tumor center are added. Next, the tumor center is segmented into four classes on region-level and four classes on cell level. Subsequently, the staining intensity is calculated to measure PD-L1 expression of each pixel (brighter pixels indicate higher intensity). Finally, image-derived features are calculated, e.g., percentage of positive tumor cells and descriptive statistics of the staining intensity distribution.

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