Table 3 Comparison of the proposed method’s predictive performance on various data distributions in five-fold cross-validation and test sets

Dataset cohort	Methods	IDH				1p/19q				Pathology types
Dataset cohort	Methods	ACC	AUC	SPE	SEN	ACC	AUC	SPE	SEN	ACC	AUC	SPE	SEN
Validation	CD	0.82	0.91	0.78	0.82	0.88	0.93	0.83	0.88	0.86	0.91	0.93	0.86
	CL	0.88	0.92	0.88	0.88	0.75	0.90	0.56	0.75	0.83	0.91	0.92	0.83
	CM	0.92	0.93	0.92	0.92	0.92	0.93	0.92	0.92	0.87	0.92	0.93	0.87
	SSL-MISS-Net	0.70	0.83	0.72	0.70	0.80	0.84	0.68	0.80	0.72	0.86	0.85	0.72
Test Set	CD	0.70	0.83	0.72	0.70	0.80	0.84	0.68	0.80	0.72	0.86	0.85	0.72
	CL	0.77	0.87	0.76	0.77	0.80	0.89	0.46	0.80	0.70	0.87	0.85	0.70
	CM	0.78	0.86	0.78	0.78	0.81	0.85	0.70	0.81	0.72	0.86	0.85	0.72
	SSL-MISS-Net	0.92	0.93	0.92	0.92	0.92	0.93	0.92	0.92	0.87	0.92	0.93	0.87

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