Table 4 Comparison of predictive performance among different reconstruction losses on the multi-center independent test datasets

Dataset cohort	Losses	IDH				1p/19q				Pathology types
Dataset cohort	Losses	ACC	AUC	SPE	SEN	ACC	AUC	SPE	SEN	ACC	AUC	SPE	SEN
Public Test Set	L1	0.84	0.91	0.86	0.84	0.86	0.89	0.76	0.86	0.85	0.87	0.86	0.72
	SSIM	0.84	0.91	0.86	0.84	0.86	0.87	0.75	0.86	0.86	0.89	0.87	0.73
	SSIM-L1	0.84	0.87	0.86	0.84	0.87	0.90	0.79	0.87	0.85	0.89	0.89	0.74
	MSE	0.87	0.93	0.88	0.87	0.89	0.92	0.82	0.89	0.89	0.91	0.91	0.79
In-house Test Set	L1	0.74	0.83	0.80	0.74	0.77	0.81	0.70	0.77	0.72	0.80	0.83	0.68
	SSIM	0.74	0.80	0.80	0.74	0.78	0.79	0.73	0.78	0.72	0.76	0.81	0.67
	SSIM-L1	0.75	0.83	0.80	0.75	0.78	0.78	0.71	0.78	0.71	0.77	0.82	0.66
	MSE	0.80	0.85	0.81	0.80	0.80	0.84	0.80	0.80	0.79	0.81	0.83	0.71

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