Table 5 Comparison of predictive performance among different methodology module on the five-fold cross-validation dataset and multi-center independent test datasets

Dataset cohort	Methods	IDH				1p/19q				Pathology types
Dataset cohort	Methods	ACC	AUC	SPE	SEN	ACC	AUC	SPE	SEN	ACC	AUC	SPE	SEN
Validation	ONF	0.89	0.90	0.82	0.89	0.89	0.93	0.88	0.89	0.85	0.93	0.92	0.85
	ONG	0.90	0.93	0.90	0.90	0.90	0.93	0.89	0.90	0.85	0.93	0.92	0.85
	SSL-MISS-Net	0.94	0.96	0.93	0.94	0.94	0.96	0.93	0.94	0.91	0.96	0.96	0.91
Public Test Set	ONF	0.81	0.87	0.84	0.81	0.83	0.84	0.70	0.83	0.72	0.85	0.89	0.72
	ONG	0.83	0.91	0.83	0.83	0.83	0.87	0.75	0.83	0.75	0.86	0.81	0.75
	SSL-MISS-Net	0.87	0.93	0.88	0.87	0.89	0.92	0.82	0.89	0.89	0.91	0.91	0.79
In-house Test Set	ONF	0.72	0.81	0.78	0.72	0.74	0.75	0.67	0.74	0.68	0.77	0.79	0.68
	ONG	0.75	0.82	0.78	0.75	0.75	0.77	0.70	0.75	0.67	0.75	0.80	0.67
	SSL-MISS-Net	0.80	0.85	0.81	0.80	0.80	0.84	0.80	0.80	0.79	0.81	0.83	0.71

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