Fig. 3: Protein-protein genetic interactions network.

Proteins within each complex, SWI/SNF (blue) and PRC2 (orange) are connected with dashed edges. Reported genetic interactions between proteins from the two complexes are drawn with continuous edges. Edge colors represent the source from the reported genetic interaction as i) extracted using RNAi experiments from Pan et al. ¹⁸ (green); ii) extracted using CRISPR experiments from Pan et al. ¹⁸ (yellow); iii) extracted using CRISPR experiments from Rauscher et al. ¹⁹ (red). A Edge width represents the score of the interaction provided by the source and node size corresponds with the number of interactions of the protein, bigger nodes are proteins with more interactions. B Set of genetic interactions extracted from Rauscher et al. ¹⁹ for EZH2. P-score and log10 (pvalue) are represented as provided in the original dataset. P-score > 0.2 represents positive genetic interactions and < −0.2 represent negative genetic interactions. PBRM1 and BRD7 are highlighted in red for visualization purposes. Each dot corresponds to one gene.