Table 1 Genetic interactions BAF/pBAF subunit and PRC2 complex
Complex1 | Complex2 | Score | Source | Brief description | Cell lines | Objective |
|---|---|---|---|---|---|---|
PBRM1 | EZH2 | 0.24 | Genetic - Rauscher et al., COESSENTIALITY, NA, Genetic Interaction Network from 85 CRISPR/Cas9 screens in human cancer cells, https://www.embopress.org/doi/full/10.15252/msb.20177656, Rauscher et al. 19 | inferred genetic interactions from CRISPR screens | 85 genome-scale CRISPR/Cas9 screens in 60 different human cancer cell lines | genetic interaction networks |
ARID1B | EED | 81 | Fitness RNAi, COESSENTIALITY, gene fitness rank correlation coefficients, 501 cancer cell lines – RNAi - Achilles Project, Reproduced following Pan et al. 18 https://figshare.com/articles/dataset/Pan_Meyers_et_al_Cell_Systems_2018_/6005297, Pan et al. 18 | gene fitness rank correlation coefficients calculated using two different RNAi- and CRISPR-Cas9-based screening datasets | 342 cell lines | discovery of protein complexes |
ARID1A | EED | 0.24 | Genetic - Rauscher et al., COESSENTIALITY, NA, Genetic Interaction Network from 85 CRISPR/Cas9 screens in human cancer cells, https://www.embopress.org/doi/full/10.15252/msb.20177656, Rauscher et al. 19 | inferred genetic interactions from CRISPR screens | 85 genome-scale CRISPR/Cas9 screens in 60 different human cancer cell lines | genetic interaction networks |
ARID1A | SUZ12 | 394 | Fitness RNAi, COESSENTIALITY, gene fitness rank correlation coefficients, 501 cancer cell lines – RNAi - Achilles Project, Reproduced following Pan et al. 18 https://figshare.com/articles/dataset/Pan_Meyers_et_al_Cell_Systems_2018_/6005297, Pan et al. 18 | gene fitness rank correlation coefficients calculated using two different RNAi- and CRISPR-Cas9-based screening datasets | 342 cell lines | discovery of protein complexes |
BRD7 | EZH2 | 493 | Fitness RNAi, COESSENTIALITY, gene fitness rank correlation coefficients, 501 cancer cell lines – RNAi - Achilles Project, Reproduced following Pan et al. 18 https://figshare.com/articles/dataset/Pan_Meyers_et_al_Cell_Systems_2018_/6005297, Pan et al. 18 | gene fitness rank correlation coefficients calculated using two different RNAi- and CRISPR-Cas9-based screening datasets | 342 cell lines | discovery of protein complexes |
BRD7 | EZH2 | 0.48 | Genetic - Rauscher et al., COESSENTIALITY, NA, Genetic Interaction Network from 85 CRISPR/Cas9 screens in human cancer cells, https://www.embopress.org/doi/full/10.15252/msb.20177656, Rauscher et al. 19 | inferred genetic interactions from CRISPR screens | 85 genome-scale CRISPR/Cas9 screens in 60 different human cancer cell lines | genetic interaction networks |
BRD7 | JARID2 | 526 | Fitness RNAi, COESSENTIALITY, gene fitness rank correlation coefficients, 501 cancer cell lines – RNAi - Achilles Project, Reproduced following Pan et al. 18 https://figshare.com/articles/dataset/Pan_Meyers_et_al_Cell_Systems_2018_/6005297, Pan et al. 18 | gene fitness rank correlation coefficients calculated using two different RNAi- and CRISPR-Cas9-based screening datasets | 342 cell lines | discovery of protein complexes |
BRD7 | SUZ12 | 100 | Fitness RNAi, COESSENTIALITY, gene fitness rank correlation coefficients, 501 cancer cell lines – RNAi - Achilles Project, Reproduced following Pan et al. 18 https://figshare.com/articles/dataset/Pan_Meyers_et_al_Cell_Systems_2018_/6005297, Pan et al. 18 | gene fitness rank correlation coefficients calculated using two different RNAi- and CRISPR-Cas9-based screening datasets | 342 cell lines | discovery of protein complexes |
