Fig. 3: Profiling of purine metabolism in scRNA-seq and ST data. | npj Precision Oncology

Fig. 3: Profiling of purine metabolism in scRNA-seq and ST data.

From: Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment

Fig. 3

a UMAP plot of 348,668 cells from scRNA-seq analysis. b Bubble plot of marker genes expressed in major cell types. c Cell type proportions in different tissue types. d, e Boxplot comparing the pathways in cancer score and purine metabolism score in epithelial cells of scRNA-seq datasets. f Spatial distribution of purine metabolism score in tissue slices from GSM6339632 and GSM6339637. g Kaplan–Meier survival analysis stratified by purine metabolism score in TCGA patients. h Kaplan-Meier survival analysis stratified by purine metabolism score in merge-GEO cohort patients.

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