Fig. 4: NT5E correlates with TME features. | npj Precision Oncology

Fig. 4: NT5E correlates with TME features.

From: Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment

Fig. 4

a Differential expression profiles of 31 purine metabolism regulators in normal (n = 44) and HNSCC samples (n = 509) from TCGA dataset. b Univariate Cox regression analysis of 23 purine metabolism regulators in TCGA and merge-GEO datasets. c Strategy for sequencing Fadu cells treated with AB680. d Heatmap showing the gene downregulation profile following AB680 treatment. e Biological pathway analysis of Fadu cells after AB680 treatment. f Schematic diagram of the screening strategy for potential receptor-ligand genes in cell-cell communication. g Bubble plot of receptor-ligand interactions between different epithelial cells and myofibroblast, INSR+ endothelial cells, and C1QA+ macrophages. Ns: no significant difference, *P < 0.05, **P ≤ 0.01, ***P ≤ 0.001.

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