Fig. 6: IL-6 promotes ubiquitination and degradation of NKp30. | npj Precision Oncology

Fig. 6: IL-6 promotes ubiquitination and degradation of NKp30.

From: Mechanistic insights into IL-6-mediated NK cell dysfunction in NSCLC via the IRE1α-XBP1s-STAT3-UBE2S axis

Fig. 6: IL-6 promotes ubiquitination and degradation of NKp30.The alternative text for this image may have been generated using AI.

a–d NCR3 expression levels in NK-92 cells treated with A549 (a, c)/PC-9 (b, d) TM CM or TG CM (n = 3). e NK-92 cells were treated with normal medium or CM and stimulated with CHX (100 ng/ml) for the indicated amount of time, after which NKp30 levels were detected via Western blotting (n = 3). f NK-92 cells were treated with DMSO or MG132 (20 mM) for 12 h, after which NKp30 was detected by Western blotting. g KEGG enrichment analyses of upregulated genes in NK cells from tumor and paracancerous tissues in NSCLC. CHX: cycloheximide; DMSO: dimethyl sulfoxide; TG: thapsigargin; TM: tunicamycin; CM: conditioned medium. Data were analyzed using one-way ANOVAs. *p < 0.05, ***p < 0.001.

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