Fig. 6: DLK1 and NOTCH1 expression in human PGL reveal cell–cell communication between neuroendocrine tumor cells and sustentacular cells. | npj Precision Oncology

Fig. 6: DLK1 and NOTCH1 expression in human PGL reveal cell–cell communication between neuroendocrine tumor cells and sustentacular cells.

From: Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas

Fig. 6

A Immunofluorescence staining for NOTCH1, DLK1, and SOX10 in a human VHL-mutated paraganglioma (PCC #1159). Neuroendocrine tumor cells show uniform DLK1 expression (green), while SOX10-expressing sustentacular cells exhibit cytoplasmic localization of NOTCH1 (red). This pattern is consistent with DLK1-mediated inhibition of NOTCH signaling and prevention of NOTCH nuclear translocation. Scale bars: 100 ÎĽm (tumor) and 10 ÎĽm (insets). B Merged (without DAPI) and single marker images of all four ROIs shown in (A). Scale bars are 10 ÎĽm. ROI, region of interest.

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