Fig. 2: Single-cell RNA sequencing reveals that HMSC is genomically and transcriptionally distinct from ACC. | npj Precision Oncology

Fig. 2: Single-cell RNA sequencing reveals that HMSC is genomically and transcriptionally distinct from ACC.

From: Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association

Fig. 2

A Heatmaps show CNVs in HMSC and ACC non-malignant (top) and malignant (bottom) single cells. Columns represent chromosomal regions; red represents amplification, while blue represents deletion. B Uniform manifold approximation and projection (UMAP) shows that primary malignant cells from HMSC cluster separately from those of ACC tumors. All cells are colored by patient. C UMAP shows MYB expression in primary malignant cells from HMSC and ACC tumors. D UMAP shows Kaye ACC score in primary malignant cells from HMSC and ACC tumors. E Bar plots show gene set enrichment analysis (GSEA) for pathways upregulated in HMSC relative to ACC (left panel, blue bars, dashed line represents false discovery rate (FDR) < 0.05) and pathways upregulated in ACC relative to HMSC (right panel, red bars, dashed line represents FDR < 0.05).

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