Fig. 4: HPV is associated with MYB in HMSC. | npj Precision Oncology

Fig. 4: HPV is associated with MYB in HMSC.

From: Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association

Fig. 4: HPV is associated with MYB in HMSC.

A Bar plot shows counts of HMSC malignant cells with the specified numbers of HPV33 reads detected. Most cells had either 0 reads (28/134) or >24 reads (105/134). B UMAP shows the distribution of HPVon cells across all HMSC malignant cells. HPVon cells are shown in blue. C Volcano plot shows differentially expressed genes (DEGs) in HPVon HMSC malignant cells with upregulated genes shown in red (FDR < 0.1, >1.25 fold-change). MYB is upregulated in HPVon cells. D Dot plot shows GSEA for pathways that are upregulated in HPVon relative to HPVoff HMSC cells (dotted line marks FDR < 0.05, color indicates significance, size indicates Normalized Enrichment Score (NES)). E Stacked bar plots show proportion of MYB+ cells by HPV status. HPVon cells show greater MYB positivity than HPVoff cells (83% vs 62%, p = 0.0224). F Violin plot shows upregulation of downstream MYB targets in HPVon cells relative to HPVoff cells in HMSC (t-test, p = 6.4 × 10−6).

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