Fig. 5: HPV is associated with MYB in OPSCC. | npj Precision Oncology

Fig. 5: HPV is associated with MYB in OPSCC.

From: Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association

Fig. 5

A Stacked bar plots show MYB+ cells by HPV status in OPSCC tumors. Higher MYB positivity (Fisher’s exact test, p < 0.05) was seen in HPVon cells for 7/10 individual OPSCC tumors. B Violin plots demonstrate upregulation of MYB targets in HPVon relative to HPVoff cells (t-test, p < 0.05) in all 10 individual OPSCC tumors. C Violin plot shows higher MYB expression in HPVon (right) versus HPVoff (left) OPSCC tumors from TCGA (t-test, p = 4.04 × 10−11). D Volcano plot shows DEGs in HPVon OPSCC malignant cells. Red represents genes upregulated in HPVon cells (FDR < 0.1, >1.25 fold-change), and green represents genes upregulated in HPVoff cells (FDR < 0.1, >1.25 fold-change). E Dot plot shows GSEA for pathways upregulated in HPVon relative to HPVoff OPSCC cells (dotted line marks FDR < 0.05, color indicates significance, size indicates NES).

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