Fig. 7: Elevated expression of pro-metastatic genes in cutaneous metastases compared to primary breast tumors. | npj Precision Oncology

Fig. 7: Elevated expression of pro-metastatic genes in cutaneous metastases compared to primary breast tumors.

From: Adipocyte-driven STAT3-ANGPT2-PTGIS axis promotes cutaneous metastasis in breast cancer and represents a targetable pathway

Fig. 7: Elevated expression of pro-metastatic genes in cutaneous metastases compared to primary breast tumors.

A Paired dot plot comparing LEP, PTGIS, ANGPT2, VEGFC, and MMP2 mRNA expression levels (logCPM) between primary tumor tissues (blue) and corresponding metastatic tissues (red) from the same patients with cutaneous metastasis only (n = 6) and multiple-organ metastasis (n = 9). B Immunohistochemical staining of LEP, p-STAT3, VEGFC, PTGIS, and ANGPT2 in patient-derived tumor and metastatic skin tissues. C Pearson analysis of the relation among STAT3, LEP, VEGFC, PTGIS, and ANGPT2. D STAT3-PTGIS-ANGPT2 signaling axis as a key promoter of skin-homing behavior in breast cancer cells.

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