Fig. 4: Treatment impacts the circadian profile which is correlated to mean treatment effect. | npj Precision Oncology

Fig. 4: Treatment impacts the circadian profile which is correlated to mean treatment effect.

From: Personalized chronotherapy in glioblastoma: integrating circadian profiling and PK–PD modelling to optimize temozolomide timing

Fig. 4

a GBM cell lines were transduced with luciferase reporters for PER2 and BMAL1 promotor, synchronized and treated at 0 h after synchronization with the indicated treatments. Bioluminescence was recorded over 4 days. b The circadian parameters normalized to the DMSO control derived from the bioluminescence data. c The Pearson correlation between mean treatment effect and normalized amplitude under treatment. Bioluminescence data acquisition was performed at least twice with 3 replicates. Icons were generated in Biorender.com.

Back to article page