Fig. 7: Simulation outcomes of coupled core-clock machinery-TMZ efficacy model. | npj Precision Oncology

Fig. 7: Simulation outcomes of coupled core-clock machinery-TMZ efficacy model.

From: Personalized chronotherapy in glioblastoma: integrating circadian profiling and PK–PD modelling to optimize temozolomide timing

Fig. 7: Simulation outcomes of coupled core-clock machinery-TMZ efficacy model.The alternative text for this image may have been generated using AI.

Cell population proliferation curves obtained from experimental studies (symbols) and simulations (lines) for a WT-, b PER2 KO-, and c NR1D1 KO T98G cell line. d–f 24 h fluctuation curves of TMZ efficacy expressed as area under the proliferation curve (AUC) for a WT-, b PER2 KO-, and c NR1D1 KO T98G cell line (error bars represent standard error of mean). Curve maximum (white triangle) and minimum (black triangle) are indicated to mark the model found optimum time point for treatment. This optimum time point corresponds to the curve minimum as proliferation inhibition is highest at this point.

Back to article page