Fig. 4: ctDNA testing is predictive of the benefit of ACT in postsurgical patients with colorectal cancer.

a Kaplan–Meier analysis of DFS stratified by adjuvant treatment (observation versus ACT) in ctDNA-positive and -negative patients with pathological high-risk stage II or stage III colorectal cancer. b Kaplan-Meier analysis of DFS and plasma ctDNA status in all patients who underwent ACT. The barplot shows the association between ctDNA status during ACT and relapse during the study period.