Fig. 2: Patch-level visualization of the morpho-molecular correlates.

The corresponding heatmaps were generated using the Grad-CAM method based on the representative patches with high confidence. The left heatmap shows the high (red)- and low (blue)-activation regions predicted to be associated with the molecular subtypes. The right patch shows the original morphological features. MSI-H microsatellite instability–high. NSMP no specific molecular profile. p53abn abnormal cellular tumor antigen p53 expression.