Table 4 Comparisons of CT findings between nodules with and without VPI in the internal and external test sets

From: Integrated predictive model for visceral pleural invasion in small NSCLC with high clinical utility

 

Pleural-attached nodules

Pleural-tag nodules

Characteristics

VPI (24)a

non-VPI (136)

Total (160)

P value

VPI (23)a

non-VPI (171)

Total (194)

P value

Nodule type

   

<0.001

   

0.004

 PSN

4 (16.67%)

99 (72.79%)

103 (64.38%)

 

11 (47.83%)

130 (76.02%)

141 (72.68%)

 

 SN

20 (83.33%)

37 (27.21%)

57 (35.63%)

 

12 (52.17%)

41 (23.98%)

53 (27.32%)

 

Mean diameter

19.75±5.08

15.69±5.85

16.30±5.91

0.002

19.53±4.84

15.58±4.79

16.05±4.94

<0.001

Nodule-pleura attachment distance (mm)

16.93±8.91

12.19±7.24

12.90±7.67

0.014

    

Nodule-pleura distance (mm)

    

5.13±2.59

5.43±4.60

5.40±4.40

0.395

Indentation

   

0.893

   

0.036

 positive

19 (79.17%)

106 (77.94%)

125 (78.13%)

 

22 (95.65%)

131 (76.61%)

153 (78.87%)

 

 negative

5 (20.83%)

30 (22.06%)

35 (21.88%)

 

1 (4.35%)

40 (23.39%)

41 (21.13%)

 

Pleural tag type

       

0.023

 I

    

0

42 (24.56%)

42 (21.65%)

 

 II

    

17 (73.91%)

102 (59.65%)

119 (61.34%)

0.581

 III

    

6 (26.09%)

27 (15.79%)

33 (17.01%)

 

PIF

    

0.51±0.13

0.29±0.22

0.32±0.22

<0.001

Jellyfish sign

   

0.006

    

 positive

11 (45.83%)

27 (19.85%)

38 (23.75%)

     

 negative

13 (54.17%)

109 (80.15%)

122 (76.25%)

     

Bridge tag sign

       

0.403

 positive

    

6 (26.09%)

32 (18.71%)

38 (19.59%)

 

 negative

    

17 (73.91%)

139 (81.29%)

156 (80.41%)

 

Involved pleural type

        

 Interlobar pleura

1 (4.17%)

42 (30.88%)

43 (26.88%)

 

0

17 (9.94%)

17 (9.76%)

 

 non-Interlobar pleura

15 (62.50%)

69 (50.74%)

84 (52.50%)

0.434

19 (82.61%)

140 (81.87%)

159 (81.96%)

0.219

 Complex pleura

8 (33.33%)

25 (18.38%)

33 (20.63%)

 

4 (17.39%)

14 (8.19%)

18 (9.28%)

 

Solid component (PSN+SN)

23

103

126

 

21

128

149

 

 Mean diameter

19.37±5.60

12.24±6.86

13.54±7.18

<0.001

16.77±4.71

11.95±5.16

12.63±5.35

<0.001

Solid component-pleura attachment distance (mm)

16.65±9.10

9.73±7.14

11.00±7.96

<0.001

    

Solid component-pleura distance (mm)

    

5.75±2.61

7.56±5.24

7.30±4.99

0.289

  1. aFive nodules, which pushed against pleura, were all pathologically confirmed with VPI.
  2. VPI visceral pleural invasion, PSN part solid nodule, SN solid nodule, PI pleural indentation, PIF pleural indentation fraction.
  3. Bold: statistically significant data.