Table 1 Baseline patient characteristics in the LIONESS study cohort
Characteristics | Category | N (% total) |
|---|---|---|
Age (years) at diagnosis | Median (range) | 64 (35-83) |
Sex | Male | 61 (80.3) |
Female | 15 (19.7) | |
Smoking history | Current/former | 66 (86.8) |
Never | 10 (13.2) | |
Pack years | Median (range) | 40 (3-150) |
Primary tumor location | Oral cavity | 21 (27.6) |
Oropharynx | 12 (15.8) | |
Hypopharynx | 15 (19.7) | |
Larynx | 28 (36.9) | |
Pathological T stage | T1 | 11 (14.5) |
T2 | 23 (30.2) | |
T3 | 32 (42.1) | |
T4 | 10 (13.2) | |
Pathological N stage | N0 | 35 (46.0) |
N1-N3 | 36 (47.4) | |
NX | 5 (6.6) | |
Extranodal extension | Yes | 16 (22.5) |
No | 55 (77.5) | |
Lymphatic vessel invasion | L0 | 56 (73.7) |
L1 | 20 (26.3) | |
Vascular invasion | V0 | 74 (97.4) |
V1 | 2 (2.6) | |
Perineural invasion | Pn0 | 66 (86.8) |
Pn1 | 10 (13.2) | |
Grading | G1 | 3 (4.2) |
G2 | 47 (66.2) | |
G3 | 20 (28.2) | |
G4 | 1 (1.4) | |
UICC stage (8th edition) | Stage I | 13 (17.1) |
Stage II | 15 (19.7) | |
Stage III | 22 (29.0) | |
Stage IVa | 15 (19.7) | |
Stage IVb | 11 (14.5) | |
p16 status | Positive | 5 (6.6) |
Negative | 71 (93.4) | |
Neck dissection | Bilateral | 60 (78.9) |
Ipsilateral | 11 (14.5) | |
None | 5 (6.6) | |
Adjuvant therapy | Radiotherapy | 18 (23.6) |
Chemoradiotherapy | 29 (38.2) | |
None (clinical controls) | 29 (38.2) |
