Fig. 1: mRNA–protein correlations across tissues and cancer-related pathways.
From: OnCorr: A pan-cancer mRNA-protein correlation tool for precision oncology
a Distribution of mRNA–protein correlations across tissues in the ProCan-DepMapSanger dataset. Only tissues with more than 10 cell lines are shown. b Histogram of mRNA–protein correlations across each cohort for ProCan-DepMapSanger (left), Clinical Proteomic Tumor Analysis Consortium (CPTAC; middle left), Cancer Cell Line Encyclopedia (CCLE; middle right) and healthy human tissue (Wang et al.22; right) datasets, with median indicated. c Boxplot showing median mRNA–protein correlations by tissue in the ProCan-DepMapSanger dataset for key biological and selected cancer-related pathways from Sanchez-Vega et al.27 and KEGG28, displayed similarly to data shown in Ghoshdastider et al.13. d Median mRNA–protein correlations of pathways from (c) for CPTAC with ProCan-DepMapSanger (upper) and with CCLE (lower). Each data point represents the median mRNA–protein correlation across tissue types in common between the datasets.
