Fig. 2: mRNA–protein correlations of cancer driver genes from OncoKB in the ProCan-DepMapSanger Dataset.

a Heatmap of mRNA–protein correlations across tissue types for cancer driver genes from OncoKB, with clusters identified by hierarchical clustering using Euclidean distance. b Violin plot showing mRNA–protein correlations of cancer driver and non-driver genes with median and standard deviation indicated. ** indicates P < 0.01 by unpaired Student’s t-test. c Distribution of mRNA–protein correlations for genes in each cluster identified in (a). Gene ontology terms with q-value < 0.05 are shown for each cluster, with all detected proteins with RNA measurements used as the list of background genes. For all plots, only genes observed in more than 10 samples in a minimum of 15 tissues (i.e., missing in fewer than five tissues) are considered.