Table 1 Patient demographics and clinical characteristics

From: Clinical validation of a tissue-agnostic genome-wide methylome enrichment assay to monitor response to pembrolizumab

Characteristic

Patients n = 64a

Age, median

60.75

Sex, n (%)

 Female

35 (54.69%)

 Male

29 (45.31%)

Cohort, n (%)

 A. Head and neck

11 (17.19%)

  HPV+

4 (36.36%)

  HPV-

1 (9.09%)

  Unknown

4 (36.36%)

  Missing

2 (18.18%)

 B. Breast

10 (15.63%)

 C. Ovarian

10 (15.63%)

 D. Melanoma

8 (12.50%)

 E. Mixed solid tumors

25 (39.06%)

Best overall response, n (%)

 Complete response

2 (3.13%)

 Partial response

13 (20.31%)

 Stable disease

16 (25.00%)

 Progressive disease

33 (51.56%)

Biomarkers

 PD-L1 expression, mean % (SD)

16.16% (32.40%)

 PD-L1 subgroups, n (%)

  <1%

33 (51.56%)

  1–49%

22 (34.38%)

  ≥50%

9 (14.06%)

Tumor mutational burden, mean (SD)b

13.61 (52.58)

  1. aMedian follow-up among surviving patients, 93.82 months.
  2. bn = 62 due to 2 patients not having tumor mutational burden data available.