Fig. 5: CD27 protein expression associated with immune cell infiltration and immunotherapy response. | npj Precision Oncology

Fig. 5: CD27 protein expression associated with immune cell infiltration and immunotherapy response.

From: CD27 expression is a clinically accessible biomarker for predicting immunotherapy response in melanoma

Fig. 5: CD27 protein expression associated with immune cell infiltration and immunotherapy response.The alternative text for this image may have been generated using AI.

A CD27/CD45RO dual fluorescence immunostaining confirming the co-localization of CD27 (yellow signal) and CD45RO (red signal) within T cells or NK cells. B Representative images showing H&E staining of tissue and cell sections, CD27 and PD-L1 IHC staining for the high and low CD27 expression groups. ×20, 20-fold original magnification; ×80, 80-fold original magnification. C Kaplan–Meier survival curve depicting progression-free survival in 102 melanoma patients treated with immunotherapy (FAHZZU) stratified by the high and low CD27 expression groups. D Box plot showing differential H-scores of CD27 (IHC) between the poor and good responders (FAHZZU cohort). E The ROC curve demonstrating the ability of the CD27 and PD-L1 H-scores (IHC) to predict immunotherapy response in the FAHZZU cohort. F Comparison of sensitivity and response rates based on CD27 and PD-L1 H-scores in melanoma patients treated with ICIs. **p < 0.01.

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