Fig. 6: Long term DNA sensing using a monolayer MoS2 nanopore (d = 6.5 nm in 1 M KCl, pH 8) with HMDS-coated substrate.
From: High durability and stability of 2D nanofluidic devices for long-term single-molecule sensing
The flow cell is sealed during the experiment and the O2-concentration in the buffer is less than 1 mg L−1. a Translocation traces of 1kbp DNA at the beginning (number of events = 1832) and the end of the measurement (number of events = 1195) at 500 mV. b Example events from the traces in (a). The dotted line is a mean fit to open pore current and the yellow fit represents CUSUM-fit to the event. c Changes in the open pore conductance (Gopen) across different time points over the course of measurement. d Violin plots showing the distribution of conductance drop due to DNA molecules translocating through the pore at different time points. The conductance drop distribution shows a median value of 4.2 nS (interquartile range of 1.66 with upper adjacent value of 7.5 and lower adjacent value of 1.3) and 3.9 nS (interquartile range of 1.69 with upper adjacent value of 7.4 and lower adjacent value of 1.6) for 30 min and 180 min pore life, respectively.
