Fig. 11: Schematic overview of MOF-based biosensing platforms for nucleic acid, exosome, and gas detection.
From: 2D MOF structure, electrochemical biosensing in bioelectronic applications
A Schematic summary illustrates the development of a label-free electro-chemical DNA biosensor based on gold nanoparticles (GNP) mediated electron transfer, providing sensitive, rapid nucleic acid detection that simplifies complex preparation processes. 109. Copyright 2021 Elsevier, B Schematic summary highlights the use of nanoscale Eu3+/Ag@UiO-66-(COOH)₂ (EAUC) composites to form a MOF-based logic gate for sensitive and selective H₂S detection and presents a promising approach for early asthma diagnosis with minimal toxicity. 110. Copyright 2019 Elsevier, C Schematic summary shows the sensitive electrochemical detection of PD-L1 positive exosomes captured using magnetic beads via the HRCA-sensitive PVP@HRP@ZIF-8 biosensor platform 111. Copyright 2020 Elsevier, D Schematic diagram shows the preparation of Fe-MOF-on-Tb-MOF and Tb-MOF-on-Fe-MOF nanostructures, along with the fabrication process for an aptasensor utilizing these two types of TbFe-MOFs. For illustrative purposes, the aptasensor based on Tb-MOF-on-Fe-MOF will be discussed as an example 112. Copyright 2019 Elsevier.
